Why do I stop taking Cymbalta for fibromyalgia?


Cymbalta belongs to a class of drugs called norepinephrine reuptake inhibitors (SNRIs). Cymbalta had previously been approved by the FDA for the treatment of depression, generalized anxiety disorders and peripheral diabetic neuropathic pain. The agency approved Cymbalta in June 2008 for the treatment of adult fibromyalgia. At first glance, duloxetine seems to be an ideal drug. This will relieve your pain andrelieve   all associated depression. Not surprisingly, Cymbalta is very successful. Today, the generic formulation of duloxetine is commonly prescribed.

How does Cymbalta work?

Scientists do not understand how Cymbalta helps patients with fibromyalgia feel better. Fibromyalgia itself is poorly understood. Many scientists believe that pain is due to changes in the nervous system that cause too many signals from nerve cells in the pain pathways. This makes a person too sensitive to things that would not normally be painful. By increasing the level of two natural substances, serotonin and noradrenaline Cymbalta, it helps to soothe these pain signals. These substances can affect the mood. They should help to control pain sensations and suppress. They are in the brain and other parts of the nervous system.

side effects

The most common adverse events were vomiting, dry mouth, constipation, decreased hunger and anorexia in the Cymbalta fibromyalgia study. The most common adverse events were nausea, dry mouth, constipation, decreased hunger, fatigue, drowsiness and increased sweating in clinical trials with Cymbalta in depression.

How to take Cymbalta?

Cymbalta is available once a day as an oral capsule. Doctors suggest that the dose should be 60 milligrams per day. On the other hand, your doctor will probably ask you to take 30 mg daily for the first week before you receive the full dose. It is important to remember that there is no evidence to suggest that taking more than 60 mg per day further reduces your pain. In fact, it increases your risk of side effects.


Cymbalta and other antidepressants may increase the risk of suicidal thoughts and behavior in persons under the age of 24. If you are prescribed Cymbalta, your doctor will monitor you closely to detect any unusual behavioral changes, new or aggravating symptoms of depression or suicidal thoughts. Cymbalta can lower blood salinity (sodium), a potentially serious condition called hyponatraemia. Older adults, especially diuretics (“water pills”), develop this complication more. Headache, confusion, weakness and, in extreme cases, hyponatremia can lead to fainting, convulsions, coma and death.

withdrawal symptoms

Although such side effects are frightening, Cymbalta has another drawback. When people try to take this medication, they often report unpleasant withdrawal symptoms, including loss of consciousness, suicidal thoughts, trembling, and vomiting. Several cases related to hospital stays. One patient said, “I have been doing Prozac for 20 years and it has finally stopped working. I took the generic Barr, the blue and white capsule, and it was the last time I took it. I felt like the deepest black hole ever.

“My doctor prescribed Cymbalta to me, which caused many side effects, such as palpitations, constant anxiety, panic attacks, sweating, drowsiness and a general sense of helplessness. do not be good. “She added Abilify, who marginalized me. I was in the worst depression I knew. After living this way for several months, I asked to be sent back to Prozac. I took the generic from Sandoz. In the end, I took the big blue and white capsules from Barr when the recipe was gone.

“In the last few weeks we have been crying constantly, arguing with everyone and feeling pretty depressed. I discussed it with my doctor and she wrote the recipe for Sandoz only in generic form. The blue and white capsules look like a placebo. My doctor told me that she had other patients who had complained about it and that she needed to write prescriptions for a particular generic or brand.

Who should not take Cymbalta?

You should not take Cymbalta if you are taking a medicine called thioridazine or a medicine called MAOI or if you have been taking any medicine for the last 14 days or if you have uncontrolled angled glaucoma. Animal studies have confirmed that Cymbalta negatively affects the development of the fetus. Pregnant or lactating women have not been adequately studied or controlled. Women should ask their doctor if Cymbalta is suitable for women who are breast-feeding, pregnant or planning to become pregnant.

You should only take Cymbalta if the benefits outweigh the risks. In rare cases, Cymbalta-treated patients have experienced life-threatening conditions known as serotonin syndrome. If a person takes two or more medications that increase the body’s serotonin levels at the same time, it can usually lead to serotonin syndrome. Serotonin is necessary for the functioning of your brain and nerve cells, but too much can be dangerous.

Serotonin syndrome can lead to rapid changes in blood pressure, muscle stiffness, seizures and even death. That’s why it’s so important for your healthcare provider to know which medications you are taking. Always tell them about any medications you are taking, including over-the-counter medicines, herbs and supplements.


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